Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1517
Protein Name
Aquaporin Z
Gene Name
aqpZ; PA4034
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Length
229 amino acids
AlphaFoldDB
AF-Q9HWZ3-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MKQYGAEFFGTFWLVLGGCGSAVLAAGVPELGIGYLGVALAFGLSVLTMAYAIGPISGAHLNPAVSVGLWVGGRFPASQLLPYVVAQVLGGLAAGGVLYLIASGKAGFDLAAGFASNGYGEHSPGGYSLQAALVSEVVLTGMFLLIILGATSKRAPQGFAPIAIGLTLTLIHLISIPVTNTSVNPARSTAVALYVGDWAVSQLWLFWVAPILGAVLGALAYRLIGDKND
PDB Structures
Ligand Binding
Binding Site
SITE 19: "Involved in tetramerization or stability of the tetramer"; SITE 42: "Selectivity filter"; SITE 172: "Selectivity filter"; SITE 181: "Selectivity filter"; SITE 187: "Selectivity filter"
Disease
Location
DOI ID
10.1038/35023079
RefSeq
NP_252723.1; WP_003102790.1